Yuen Siang Ang - University of Oxford

Yuen-Siang Ang, D.Phil.

Postdoctoral Fellow, McLean Hospital
Department of Psychiatry, Harvard Medical School


My Research

Deficits in motivation (e.g. apathy, anhedonia) are profoundly disabling and prevalent in neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, and psychiatric disorders, such as Major Depressive Disorder and schizophrenia. My research uses computational modelling, functional neuroimaging and pharmacological challenge techniques to understand how impairments during decision making in humans may contribute to reduced goal-directed behaviour in these conditions. The overall goal is to improve diagnostic precision and enhance treatment efficacy of motivational dysfunction across diagnoses.

Questions I am currently investigating include:
1. What are the psychological and neurocognitive mechanisms underlying processes in decision-making? (see e.g. Ang et al. 2018, Current Biology)
2. How might deficits in decision-making processes contribute to disorders in motivation in conditions such as Parkinson's disease and Major Depressive Disorder?
3. Can we identify subtypes within apathy and depression? (see e.g. Ang et al. 2017, PLoS One; Ang et al. 2018, Annals of Clinical and Translational Neurology)
4. Can we develop useful predictive models of antidepressant treatment outcomes with machine learning algorithms?

Contact me at yang@mclean.harvard.edu if you have any questions regarding my research or are interested in collaborating! Click here for my Google Scholar profile.